"Revisiting this gloriously anarchic, ceaselessly inventive bliss machine (which I saw bits and pieces of a gazillion times in first run, working concessions at a multiplex where it played) made me realize how un-daffy—or perhaps un-Daffy—American film comedy has since become."
— Mike D'Angelo, Listen Eggroll
"PEE-WEE'S BIG ADVENTURE is of course the feature debut of Tim Burton, who is perhaps the perfect directorial match for Reubens' funhouse comedy, and the film offers the curious objects, candy colors, and spoiled suburban malaise that have since become the hallmarks of Burton's all too successful career."
— Liam Neff, Cine-File
"[Pee-Wee's Big Adventure] remains [Burton's] most emotionally-honest and just plain funnest movie. Its plot is a skeleton upon which, in best silent comedy fashion, vignettes stuffed with gags are draped. The end result is an unlikely fusion of BICYCLE THEIVES and PORKY IN WACKYLAND, Buñuel on laughing gas, Raymond-Scott-by-way-of-Danny-Elfman and Rube-Goldberg-meets-Ronald-Reagan."
— Rob Christopher, Cine-File